New way to isolate DNA- and RNA-protein complexes

New method using silica-based columns simplifies the extraction of DNA – and RNA-protein complexes. IMAGE: Adobe stock
New method using silica-based columns simplifies the extraction of DNA – and RNA-protein complexes. IMAGE: Adobe stock

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EMBL researchers develop method that simplifies the isolation of DNA- and RNA- protein complexes

By interacting with nucleic acids (DNA and RNA), proteins create complexes that regulate cell behaviour. In order to understand how these complexes regulate cell function, they must be isolated from nucleic acids. Claudio Asencio, a researcher in the Hentze group, has developed a new method, called Complex Capture (2C), that simplifies the extraction of complexes by using silica-based extraction columns commonly used in labs to purify nucleic acids.