EMBL in six objects

A stylised birds eye view of the EMBL Heidelberg Campus in green, black and white.

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A history of EMBL in six objects from the EMBL Archive

By Anne-Flore Laloë

Every year, on 9 June, archivists all around the world celebrate International Archives Day to raise awareness about the role of archives in collecting, preserving and sharing humanity’s heritage.

This year, at EMBL, 9 June also marks six weeks until the inauguration of the EMBL Archive. This will be held on 19 July at EMBL’s Heidelberg site. The EMBL Archive is a new resource, which captures, preserves and makes available scientific and institutional material from EMBL’s past and present for the future.

Ahead of the inauguration, here is a preview of some material from EMBL’s past. We will reveal one item a week until the inauguration and explain how it connects to the present and future of European molecular biology – so stay tuned!

International beginnings

May 1978, EMBL’s first site, the headquarters in Heidelberg, was officially opened with an inauguration ceremony. At that event, immunologist Michael Sela gave a speech on science and international collaboration. His message still rings true today: “the basic nature of science is authentically international”.

The progress of molecular biology over the past 20 years has been encr m-ous. It has, in fact, resulted in the popularly-held view - among laymen - that the achievements of biology in the second half of this century are commensurate in scope with those of physics in the first half. But the truth is that the greatest challenges of modern biology are still before us - and in these future develop-ments the EMBO Laboratory will unquestionably play a crucial role. This Heidelberg Laboratory will, I am sure, become a central force and catalyst, an honest broker of information and a leader in the new pathways of research while serving also as a home away from home for scientists from all over Europe, and from other parts of the world as well. By so doing, it will prove conclusively that the basic nature of science is authentically international.

That is something that has been ingrained in EMBL’s very foundations. From 10 member states when it was founded in 1974, EMBL today has over 20 member states. Scientists from these countries can access all EMBL services and programmes. Member states are also responsible for all important decisions about the organisation and its activities.

EMBL is now made up of over 1700 people from over 80 countries worldwide working across six sites. Over 7000 people travel each year to one of EMBL’s courses or conferences. The future of science is international and global.

On 19 July 2018, at the inauguration of the EMBL Archive, Michael Sela will return to EMBL Heidelberg to give another speech. He will travel from Israel to Germany to do so.

Cellular organisation

This cover, from EMBL’s 1991 Research Report (DE 2324 C-PUBS-C-16) illustrates work carried out that year to study how the inside of cells are organised. When cells divide the structures inside are dramatically altered: the chromosomes condense, the nuclear envelope fragments and microtubules reorganise and form the mitotic spindle. In 1991, several groups at EMBL were studying what happened cell division. In this image, the panels on the left show cells during interphase, or “normal” phase. On the right, cells during division (mitosis). The upper panels display the microtubules (green) and DNA of the chromosomes (grey) as observed after double labelling in the confocal microscope. The lower panels show a graphical representation of the cellular organelles during these processes.

cells during interphase and division in grey and green

Today, in comparison, we can see individual condensin proteins bound to chromosomes during the different stages of cell division using quantitative live cell imaging, and we can even watch those condensins form.

Locations of Condensins I and II on chromosomes during cell division

Locations of Condensins I and II (green) on chromosomes (magenta) during cell division
IMAGE: EMBL/Nike Walther

EMBL’s Research Reports were one way that EMBL made its research activities public. Later called Research at a Glance and now Research in Brief, a full history of these publications is accessible in the EMBL Archive’s “EMBL Institutional Publications” collection.

Prize winning equipment

In 2017, EMBL alumnus Jacques Dubochet, together with Joachim Frank and Richard Henderson, was awarded the Nobel Prize in Chemistry “for developing cryo-electron microscopy for the high-resolution structure determination of biomolecules in solution.”

Dubochet was at EMBL from between 1978 and 1987, a period during which he worked closely with EMBL’s workshops to develop instruments, in particular a cryo-holder and a cryo-plunger that prepare samples to be put into the large electron microscope. Today, cryo-electron microscopy represents one of EMBL’s major areas of research and service provision. Although the equipment does look a little different today it is still recognisable from Dubochet’s work.

Wim Hagen and Jacques Dubochet compare old and new. IMAGE: EMBL

The Electron Microscopy Core Facility in Heidelberg, and the cryo-EM facility in Grenoble give users to access cutting-edge instruments and support, and EMBL scientists continue to innovate and create new techniques, such as correlative light and electron microscopy (CLEM).